Subject(s)
Humans , Male , Middle Aged , Stroke Volume , Heart Failure/diagnosis , Heart Failure/physiopathology , Paralysis/complications , Paralysis/blood , Phrenic Nerve , Biomarkers/blood , Peripheral Nervous System Diseases/complications , Peripheral Nervous System Diseases/blood , Heart Failure/complications , Heart Failure/bloodABSTRACT
Diseases of the peripheral nervous system are the most prevalent in patients with end-stage renal disease (ESRD). Although increased blood levels of lead in ESRD have been reported, the role of lead remains to be elucidated. The purpose of this study was to determine the connection of blood lead concentration with peripheral nerve conduction velocity. One hundred ninety-eight healthy subjects (control group) and 68 patients with ESRD undergoing hemodialysis (ESRD group) were enrolled. Nerve conduction was measured within two hours after hemodialysis. Orthodromic sensory nerve action potentials and compound muscle action potentials were recorded on the median, ulnar, and radial nerves. Hemoglobin-corrected blood lead was significantly higher in ESRD patients than in controls (9.1+/-2.8 microgram/dL vs. 5.9+/-2.3 microgram/dL, p0.05). Our result suggested that even though the blood lead levels were high in ESRD, they were not associated with the decline of peripheral nerve function. Diabetes mellitus is a primary independent risk of neuropathy in ESRD patients.
Subject(s)
Middle Aged , Male , Humans , Female , Adult , Peripheral Nervous System Diseases/blood , Peripheral Nerves/physiopathology , Neural Conduction/physiology , Lead/blood , Kidney Failure, Chronic/blood , Diabetic Neuropathies/blood , Case-Control Studies , Bone and Bones/metabolism , Body BurdenABSTRACT
Three pediatric patients with Cuban epidemic neuropathy were studied. Cerebrospinal fluid and sera were simultaneously obtained. Albumin and IgG were quantified by immunodifusion. Albumin quotient and local synthesis of IgG were calculated by Reibert/Felgenhauer formula. A patient with optic neuritis had a dysfunction of the blood-cerebrospinal fluid barrier. All the group had local synthesis of IgG.
Subject(s)
Humans , Male , Female , Child , Peripheral Nervous System Diseases/blood , Immunoglobulin G/biosynthesis , Optic Neuritis/blood , Serum Albumin/analysis , Cuba , Peripheral Nervous System Diseases/cerebrospinal fluid , Immunoglobulin G/analysis , Immunoglobulin G/cerebrospinal fluid , Optic Neuritis/diagnosis , Optic Neuritis/cerebrospinal fluidABSTRACT
In a group of 34 industrial workers, chronically exposed to organophosphorus (OP) compounds, serum pseudocholinesterase activity was depressed significantly in the exposed group as compared to the control group. There was a significantly higher incidence of peripheral neuropathy among the workers exposed to OP compounds, as compared to the control group. Mild to profound sensorineural hearing deficits were detected in both the exposed and control groups. As the pre-exposure hearing status of the workers was not known and since many other factors can also cause pathological changes in the cochlear nerve, a definite conclusion about the ototoxic nature of the OP compounds could not be drawn.